文摘
Glucocorticoids cause ocular hypertension/glaucoma, but only in a subset of patients. Glucocorticoids affect expression of many genes, variants in which could alter response. Pharmacogenomics can identify genetic variants affecting glucocorticoid sensitivity. The location of variants can pinpoint new causative genes and clinically relevant pathways. Testing for identified variants can be used to predict glucocorticoid sensitivity in patients.