- 作者：Eileen Rakovitch ; MD ; FRCPC&lowast ; ; &dagger ; ; &Dagger ; ; Eileen.rakovitch@sunnybrook.ca ; Steven A. Narod ; MD ; FRCPC&Dagger ; ; § ; ; Sharon Nofech-Moses ; MD ; FRCPC&lowast ; ; &Dagger ; ; Wedad Hanna ; MD ; FRCPC&lowast ; ; &Dagger ; ; Deva Thiruchelvam ; MSc&dagger ; ; Refik Saskin ; MSc&dagger ; ; Carole Taylor ; MSc&dagger ; ; Alan Tuck ; MD ; FRCPC¡¬ ; Bruce Youngson ; MD ; FRCPC¶ ; ; Naomi Miller ; MD ; FRCPC¶ ; ; Susan J. Done ; MB ; BChir ; PhD ; FRCPC¶ ; ; Sandip Sengupta ; MD ; FRCPC# ; Leela Elavathil ; MD ; FRCPC&Dagger ; ; &lowast ; &lowast ; ; Prashant A. Jani ; MD ; FCAP ; FRCPC&Dagger ; ; &dagger ; &dagger ; ; Michel Bonin ; MD ; FRCPC&Dagger ; &Dagger ; ; Stephanie Metcalfe ; MSc&lowast ; ; Lawrence Paszat ; MD ; FRCPC&lowast ; ; &dagger ; ; &Dagger ;
- 刊名：International Journal of Radiation Oncology*Biology*Physics
- 出版年：2013
- 出版时间：1 July, 2013
- 年：2013
- 卷：86
- 期：3
- 页码：491-497
- 全文大小：472 K
Purpose
To report the outcomes of a population of women with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery and radiation and to evaluate the independent effect of boost radiation on the development of local recurrence.Methods and Materials
All women diagnosed with DCIS and treated with breast-conserving surgery and radiation therapy in Ontario from 1994 to 2003 were identified. Treatments and outcomes were identified through administrative databases and validated by chart review. The impact of boost radiation on the development of local recurrence was determined using survival analyses.
Results
We identified 1895 cases of DCIS that were treated by breast-conserving surgery and radiation therapy; 561 patients received boost radiation. The cumulative 10-year rate of local recurrence was 13 % for women who received boost radiation and 12 % for those who did not (P=.3). The 10-year local recurrence-free survival (LRFS) rate among women who did and who did not receive boost radiation was 88 % and 87 % , respectively (P=.27), 94 % and 93 % for invasive LRFS (P=.58), and was 95 % and 93 % for DCIS LRFS (P=.31). On multivariable analyses, boost radiation was not associated with a lower risk of local recurrence (hazard ratio = 0.82, 95 % confidence interval 0.59-1.15) (P=.25).
Conclusions
Among a population of women treated with breast-conserving surgery and radiation for DCIS, additional (boost) radiation was not associated with a lower risk of local or invasive recurrence.