Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification

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• 作者：Lucja T. Grajkowska¹ ; ² ; Michele Ceribelli³ ; ⁴ ; Colleen M. Lau¹ ; Margaret E. Warren¹ ; ⁵ ; Ioanna Tiniakou¹ ; Sandra Nakandakari Higa¹ ; Anna Bunin² ; Hans Haecker⁶ ; Leonid A. Mirny⁷ ; Louis M. Staudt³ ; Boris Reizis¹ ; ² ; ⁸ ; ^{boris.reizis@nyumc.org}
• 关键词：dendritic cells ; plasmacytoid dendritic cells ; transcription factors ; E proteins ; enhancers ; feedback regulation
• 刊名：Immunity
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：46
• 期：1
• 页码：65-77
• 全文大小：3702 K
• 卷排序：46

文摘

Two functional isoforms of the E protein factor TCF4 (E2-2) are expressed in pDCs The “long” TCF4 isoform is pDC specific and controls pDC development in vivo A conserved enhancer controls TCF4 expression and pDC development TCF4 expression and pDC development are sensitive to BET protein inhibitors