TCTP regulates spindle microtubule dynamics by stabilizing polar microtubules during mouse oocyte meiosis
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- 作者：Hyuk-Joon Jeona ; Seung Yeop Youa ; Yong Seok Parka ; Jong Wook Changb ; c ; Jae-Sung Kimd ; Jeong Su Oha ; ohjs@skku.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oocyte ; Meiosis ; TCTP ; Microtubule ; Spindle
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1863
- 期：4
- 页码：630-637
- 全文大小：2337 K
文摘
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TCTP is associated with spindle during meiotic maturation in mouse oocytes.
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TCTP is required for proper spindle organization but not for chromosome alignment.
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TCTP is required to stabilize polar microtubules but not kinetochore microtubules.
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TCTP phosphorylation is required for spindle depolymerization.
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TCTP is associated with Plk1.