Lab-on-a-chip technologies for genodermatoses: Recent progress and future perspectives

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• 作者：Cui Hongzhou^a ; ¹Author Vitae ; Guo Shuping^a ; ¹ ; Wang Wenju^b ; ¹ ; Li Li^a ; Wei Lulu^a ; Deng Linjun^a ; Li Jingmin^a ; Ren Xiaoli^a ; Bai Li^a ; ^{baili@medmail.com.cn}
• 关键词：Lab-on-a-chip ; Genodermatoses ; Accumulated mutations ; Microfludic mutation screening ; Molecular diagnosis
• 刊名：Journal of Dermatological Science
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：85
• 期：2
• 页码：71-76
• 全文大小：560 K
• 卷排序：85

文摘

In recent years, molecular biology has proven to be a great asset in our understanding of mechanisms in genodermatoses. However, bench to bedside translation research lags far behind. Advances in lab-on-a-chip technologies enabled programmable, reconfigurable, and scalable manipulation of a variety of laboratory procedures. Sample preparation, microfluidic reactions, and continuous monitoring systems can be integrated on a small chip. These advantages have attracted attention in various fields of clinical application including diagnosis of inherited skin diseases. This review lists an overview of the underlying genes and mutations and describes prospective application of lab-on-a-chip technologies as solutions to challenges for point-of-care genodematoses diagnosis.