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A comparative meta-analysis of TEMPS scores across mood disorder patients, their first-degree relatives, healthy controls, and other psychiatric disorders
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The first meta-analysis of TEMPS score across psychiatric disorders, their relatives, and healthy controls.

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26 studies, 2025 patients with BD, 1283 with MDD, 56 with ADHD, 43 with BPD, 436 relatives of BD, and 1757 HCs.

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Cyclothymic,and irritable TEMPS scores develop on a continuum, from HCs through MDD to BD.

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Cyclothymic, irritable and anxious scores develop on a continuum from HCs, through BD relatives to BD.

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No difference in any TEMPS score between BD and ADHD.

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