A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathway
详细信息 查看全文
- 作者：Manik Chandra Shilla ; Hiroyuki Mizuguchia ; guchi003@tokushima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Sanmoy Karmakarb ; Takuya Kadotaa ; Pulok K. Mukherjeeb ; Yoshiaki Kitamurac ; Yoshiki Kashiwadad ; Hisao Nemotoe ; Noriaki Takedac ; Hiroyuki Fukuif
- 关键词：BSA ; bovine serum albumin ; ERK ; extracellular signal-regulated kinase ; FBS ; fetal bovine serum ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; H1R ; histamine H1 receptor ; IL ; interleukin ; PKCδ ; protein kinase C-δ ; PMA ; phorbol 12-myristate 13-acetate ; RT-PCR ; reverse transcription-polymerase chain reaction ; TDI ; toluene-2 ; 4-diisocyanate ; Th2 ; helper T cell type 2
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：18-26
- 全文大小：1092 K
文摘
- •
MBCA suppressed PMA-induced H1R upregulation at both mRNA and protein levels.
- •
MBCA inhibited PMA-induced phosphorylation of Tyr311 of PKCδ.
- •
MBCA inhibited PMA-induced translocation of PKCδ from the cytosol to the Golgi.
- •
MBCA suppressed nasal symptoms and H1R mRNA induction in TDI-sensitized rats.
- •
Mechanism of H1R gene suppression by MBCA underlies the inhibition of PKCδ signaling.