Protective effect of quercetin in gentamicin-induced oxidative stress in vitro and in vivo in blood cells. Effect on gentamicin antimicrobial activity

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• 作者：Pamela Soledad Bustos^a ; ^b ; ^{pbustos@fcq.unc.edu.ar} ; Romina Deza-Ponzio^d ; ^e ; ^{rdezaponzio@fcq.unc.edu.ar} ; Paulina Laura Pá ; ez^a ; ^c ; ^{plpaez@fcq.unc.edu.ar} ; Ines Albesa^a ; ^b ; ^{inesalbesa@fcq.unc.edu.ar} ; José ; Luis Cabrera^b ; ^{jcabrera@fcq.unc.edu.ar} ; Miriam Beatriz Virgolini^d ; ^e ; ^{mvirgoli@fcq.unc.edu.ar} ; Marí ; a Gabriela Ortega^a ; ^b ; ^{gortega@fcq.unc.edu.ar}
• 关键词：ROS ; reactive oxygen species ; SOD ; superoxide dismutase ; CAT ; catalase ; GEN ; gentamicin ; Q ; quercetin ; H2DCFDA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein diacetate ; NBT ; nitroblue tetrazolium ; EDTA ; ethylenediaminetetraacetic acid ; MDA ; malondialdehide ; TBA ; 2-thiobarbituric acid ; TCA ; trichloroacetic ; HBSS ; Hank&rsquo ; s balanced salt solution ; PMN ; polymorphonuclear leukocytes ; MN ; mononuclear leukocytes ; MIC ; minimal inhibitory concentration ; DMSO ; dimethyl sulfoxide ; TBARS ; thiobarbituric
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：48
• 期：Complete
• 页码：253-264
• 全文大小：1580 K
• 卷排序：48

文摘

Gentamicin, at therapeutic doses, induces oxidative stress in whole blood cells. Quercetin could produce a protective effect against the toxicity of gentamicin. Quercetin does not change the antibacterial activity of gentamicin against E. coli. Quercetin contributes to antibacterial activity of gentamicin against S. aureus.