Acute exposure to a Mn/Zn ethylene-bis-dithiocarbamate fungicide leads to mitochondrial dysfunction and increased reactive oxygen species production in Caenorhabditis elegans

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• 作者：Callie E. Todt^a ; ^{ctodt@student.king.edu} ; Denise C. Bailey^a ; ^{dbailey@student.king.edu} ; Aireal S. Pressley^a ; ^{adpressley@outlook.com} ; Sarah E. Orfield^a ; ^{seorfield@student.king.edu} ; Rachel D. Denney^a ; ^{radonaldson@student.king.edu} ; Isaac B. Snapp^a ; ^{snapp@musc.edu} ; Rekek Negga^a ; ^{rnegga@utk.edu} ; Andrew C. Bailey^a ; ^{abailey@student.king.edu} ; Kara M. Montgomery^a ; ^{kmontgomery@student.king.edu} ; Wendy L. Traynor^b ; ^{wltrayno@king.edu} ; Vanessa A. Fitsanakis^a ; ^{vafitsan@king.edu}
• 关键词：PD ; Parkinson&rsquo ; s disease ; MZ ; Manzate ; Mn/Zn-EBDC ; Mn/Zn ethylene-bis-dithiocarbamate ; C. elegans ; Caenorhabditis elegans ; ROS ; reactive oxygen species ; E. coli ; Escherichia coli ; CGC ; Caenorhabditis Genetics Center ; GFP ; Green fluorescent protein ; NGM ; nematode growth media ; EDTA ; ethylene diamine tetraacetic acid ; EGTA ; ethylene glycol tetraacetic acid ; NBT ; nitroblue tetrazolium ; DAB ; 3 ; 3&prime ; -diaminobenzidine ; TMRE ; tetramethylrhodamine ethyl ester ; DMSO ; dimethyl sulfoxide ; DHE ; dihy
• 刊名：NeuroToxicology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：57
• 期：Complete
• 页码：112-120
• 全文大小：1486 K
• 卷排序：57

文摘

C. elegans acutely treated with manzate show reduced ATP levels. The decreased ATP may be attributed to Complex III inhibition. Mitochondrial inhibition is associated with increased hydrogen peroxide levels. Increased glutathione-S-transferase levels correlate with oxidative stress. Mitochondrial inhibition and oxidative stress may be mechanisms of manzate toxicity.