Periplocoside A ameliorated type II collagen-induced arthritis in mice via regulation of the balance of Th17/Treg cells

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• 作者：Yang Yang^a ; Xudong Hu^a ; Lei Cheng^b ; Wei Tang^b ; Weimin Zhao^c ; Yifu Yang^a ; ; Jianping Zuo^a ; ^b ; ^{jpzuo@mail.shcnc.ac.cn}
• 关键词：Periplocoside A ; Collagen-induced arthritis ; Th17 cell ; Regulatory T cell ; Rheumatoid arthritis ; Immunosuppression
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：43-52
• 全文大小：1342 K
• 卷排序：44

文摘

Periplocoside A (PSA) came from Periploca sepium Bge which is a traditional Chinese herbal to treat rheumatoid arthritis (RA) for a long time. This is the first time to study on the mechanism of PSA on type II collagen-induced arthritis (CIA) in DBA/1 mice. Life is a balance system, the regulation of balance is a tendency in current disease therapy. PSA inhibits Th17 and enhances Treg cells in CIA mice. Thus PSA could systematically regulate the balance of life which played a very important role in disease therapy. The pharmacological mechanism of PSA to treat RA is different from that of the current drugs, which may provide a alternative way for RA treatment.