Synthesis and characterization of five-coordinate rhenium(V) and technetium(V) mixed ligand bifunctional complexes carrying the SNS/S or the SNN/S donor atom set. Crystal structure of ReO{[(C2H5)2NCH2CH2
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- 作者：Papadopoulos ; Minas ; Tsoukalas ; Charalabos ; Pirmettis ; Ioannis ; Nock ; Berthold ; Maina ; Theodosia ; et. al.
- 关键词：Crystal structures ; Rhenium complexes ; Technetium complexes ; Mixed ligand complexes ; Bifunctional complexes
- 刊名：Inorganica Chimica Acta
- 出版年：1999
- 出版时间：February 2, 1999
- 年：1999
- 卷：285
- 期：1
- 页码：97-106
- 全文大小：211 K
文摘
Two parallel series of bifunctional mixed ligand oxorhenium and oxotechnetium complexes containing the SNS/S or the SNN/S donor atom set are synthesized and characterized in this study. The amine bifunctional anchor is positioned on the common monothiolate p-H2N–Ph–SH coligand, which by reacting in equimolar amounts with a tridentate aminethiolate ligand LH2 [LH2:CH3CH2N(CH2CH2SH)2, (CH3CH2)2NCH2–CH2N(CH2CH2SH)2, (CH2)4NCH2CH2NHCH2CH2SH and (CH3CH2)2NCH2CH2NH–CH2CH2SH] and the corresponding oxometal precursor, leads to the generation of these series. Two representative members ReO{[(C2H5)2NCH2CH2N(CH2CH2S)2](p-H2N–PhS)} and ReO{[(CH2)4NCH2CH2NCH2CH2S](p-H2N–PhS)} are further characterized by crystallographic analysis. The SNS/S analogs adopt a distorted trigonal bipyramidal geometry, while the SNN/S ones prefer a distorted square pyramidal geometry around the metal. Extrapolation of structure at tracer level is investigated by chromatographic methods and is established only for the SNS/S, but not for the SNN/S compounds. Thus, by this initial evaluation, the applicability of the bifunctional SNS/S (but not the SNN/S) system for tagging biomolecules with 99mTc is demonstrated.