Tfh cell-mediated humoral immune response and HBsAg level can predict HBeAg seroconversion in chronic hepatitis B patients receiving peginterferon-α therapy
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- 作者：Li Zhang1 ; Miao Zhang1 ; Hu Li ; Zhiwei Chen ; Aoran Luo ; Bin Liu ; Min Chen ; Mingli Peng ; Hong Ren ; Peng Hu ; hp_cq@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HBV ; hepatitis B virus ; CHB ; chronic hepatitis B ; HCC ; hepatocellular carcinoma ; HBeAg ; hepatitis B e antigen ; Ab ; antibody ; anti-HBe ; antibodies against HBeAg ; PEG-IFN-α ; pegylated interferon alpha ; Tfh ; follicular T helper cells ; CXCR5 ; chemokine (C-X-C motif) receptor 5 ; ICOS ; inducible co-stimulators ; ICOSL ; ICOS ligands ; PD-1 ; programmed cell death-1 ; PD-L1 ; PD-1 ligands-1 ; CD40L ; CD40 ligands ; IL-21 ; interleukin 21 ; IL-21R ; IL-21 receptors ; ALT ; alanine aminotransferase ; HBsAg ; hepatitis B
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：37-45
- 全文大小：1988 K
文摘
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Higher frequency of circulating TFH cells is found in patients with HBeAg seroconversion.
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HBeAg seroconversion is associated with higher frequency of CD19+CD38+ B cells.
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Dysfunction of humoral immune response may causes the failure of HBeAg seroconversion.
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The TFH cells/HBsAg ratio is an ideal marker for predicting HBeAg seroconversion.