Necroptosis mediates the antineoplastic effects of the soluble fraction of polysaccharide from red wine in Walker-256 tumor-bearing rats

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• 作者：Maria Carolina Stipp^a ; Iglesias de Lacerda Bezerra^b ; Claudia Rita Corso^a ; Francislaine A. dos Reis Livero^a ; Luiz Alexandre Lomba^a ; Adriana Rute Cordeiro Caillot^b ; Aleksander Roberto Zampronio^a ; José ; Ederaldo Queiroz-Telles^c ; Giseli Klassen^d ; Edneia A.S. Ramos^d ; Guilherme Lanzi Sassaki^b ; Alexandra Acco^a ; ^{aleacco@ufpr.br}
• 关键词：TriZol Reagent ; buffered 10% formalin ; ethanol ; xylol ; paraffin ; hematoxylin and eosin (HE) ; phosphate buffer (pH 6.5) ; Griess solution (0.1% N-1-naphthyl-tilediamine ; 1% sulfanilamide in 5% H3PO4) ; saline Triton X-100 0.1% ; TMB 18.4&thinsp ; mM ; dimethylformamide 8% ; sodium acetate (NaOAc) ; p-nitrophenyl-N-acetyl-β-d-glucosamine ; N-acetyl-β-d-glucosamine ; p-nitrofen ; ketamine hydrochloride ; xylazine hydrochloride ; metothrexate ; phosphate buffered saline (PBS ; 16.5&thinsp ; mM phosphate ; 137&thinsp
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：160
• 期：Complete
• 页码：123-133
• 全文大小：2483 K
• 卷排序：160

文摘

Soluble fraction of polysaccharide extracted from cabernet franc wine has a complex mixture, with arabinogalactans, mannans and rhamnogalacturonans. Soluble fraction of polysaccharide showed and expressive antineoplastic effects against the Walker-256 tumor in rats. Soluble fraction of polysaccharide increased the tumor TNF-α production and activated the necroptosis pathway. Soluble fraction of polysaccharide may be a potential therapy for cancers that are modulated by immune/inflammatory processes.