Here, we investigated the effects of tropisetron and lipopolysaccharide (LPS) on the expression of 5HT3 receptor A,B,C,D,E mRNA levels by real time PCR and FACS analysis.
Our data indicate that the different 5-HT3 receptor subtypes are modulated at its transcriptional and surface expression level by inflammatory conditions and 5-HT3 antagonists such as tropisetron in primary human monocytes.
5-HT3 receptor antagonists are therefore a new and promising therapeutic option. New and more selective - in respect to the 5-HT3 subtypes - 5-HT3R antagonists might be a future perspective in the pharmacological treatment of inflammatory diseases such as rheumatoid arthritis.