Extending the scope of pooled analyses of individual patient biomarker data from heterogeneous laboratory platforms and cohorts using merging algorithms
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- 作者：Ó ; rlaith Burkea ; 1 ; 2 ; 3 ; orlaith.burke@ndph.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Samantha Bentonb ; 1 ; 2 ; 3 ; Pawel Szafranskic ; 1 ; Peter von Dadelszenb ; 1 ; S. Catalin Buhimschid ; Irene Cetine ; Lucy Chappellf ; Francesc Figuerasg ; Alberto Galindoh ; Ignacio Herraizh ; Claudia Holzmani ; Carl Hubelj ; Ulla Knudsenk ; Camilla Kronborgl ; Hannele Laivuorim ; Olav Lapairen ; Thomas McElratho ; Manfred Moertlp ; Jenny Myersq ; Roberta B. Nessr ; Leandro Oliveiras ; Gayle Olsont ; Lucilla Postonf ; Carrie Ris-Stalpersu ; James M. Robertsj ; Sarah Schalekamp-Timmermansv ; Dietmar Schlembachw ; Eric Steegersv ; Holger Stepanx ; Vassilis Tsatsarisy ; Joris A. van der Postu ; Stefan Verlohrenz ; Pia M. Villaaa ; David Williamsbb ; Harald Zeislercc ; Christopher W.G. Redmanc ; 1 ; Anne Cathrine Staffdd ; 1 ; for the Global Pregnancy Collaboration
- 关键词：PlGF ; placental growth factor ; HDP ; hypertensive disorders of pregnancy ; BRC ; best reference curve ; IPD ; individual patient data ; GA ; gestational age ; MoM ; Multiple of the Median ; CI ; confidence interval
- 刊名：Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：6
- 期：1
- 页码：53-59
- 全文大小：821 K
文摘
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Successful merging of individual pregnancy data across heterogeneous platforms.
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Global standardized PlGF measure developed for use, irrespective of local platform.
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Best reference curve for PlGF measurements created for normal pregnancy.
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Successful use of reference curve for identification of adverse outcomes.
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Method can be extended to any biomarkers from heterogeneous platforms in any field.