Unraveling the Biological Roles of Reactive Oxygen Species

详细信息    查看全文

• 作者：Michael  ; P. Murphy¹ ; ^{mpm@mrc-mbu.cam.ac.uk} ; Arne Holmgren² ; Nils-Gö ; ran Larsson³ ; Barry Halliwell⁴ ; Christopher  ; J. Chang⁵ ; ⁶ ; Balaraman Kalyanaraman⁷ ; ⁸ ; Sue  ; Goo Rhee⁹ ; Paul  ; J. Thornalley¹⁰ ; Linda Partridge¹¹ ; David Gems¹¹ ; Thomas Nyströ ; m¹² ; Vsevolod Belousov¹³ ; Paul  ; T. Schumacker¹⁴ ; Christine  ; C. Winterbourn¹⁵
• 刊名：Cell Metabolism
• 出版年：2011
• 出版时间：6 April 2011
• 年：2011
• 卷：13
• 期：4
• 页码：361-366
• 全文大小：137 K

文摘

Summary

Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.