Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development

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• 作者：Norimasa Iwanami¹ ; Katarzyna Sikora¹ ; ² ; Andreas S. Richter² ; ³ ; Maren Mö ; nnich¹ ; ⁴ ; Lucia Guerri¹ ; ⁵ ; Cristian Soza-Ried¹ ; ⁶ ; Divine-Fondzenyuy Lawir¹ ; Fernando Mateos¹ ; Isabell Hess¹ ; Connor P. O&rsquo ; Meara¹ ; Michael Schorpp¹ ; Thomas Boehm¹ ; ⁷ ; ^{boehm@immunbio.mpg.de}
• 关键词：T cell development ; genetic screen ; immunodeficiency ; zebrafish ; mouse ; pre-mRNA splicing
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2259-2270
• 全文大小：3317 K
• 卷排序：17

文摘

Forward genetic screens identify mutations affecting zebrafish T cell development Identification of il7r, jak3, and pole1 mutations validates specificity of screen design Mutations in pre-mRNA-processing factor genes reveal evolutionarily conserved pathway In zebrafish and mice, TNPO3 deficiency impairs T cell differentiation