Comparative evaluation of non-contrast CAIPIRINHA-VIBE 3T-MRI and multidetector CT for detection of pulmonary nodules: In vivo evaluation of diagnostic accuracy and image quality

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• 作者：Patricia Dewes ; Claudia Frellesen ; Firas Al-Butmeh ; Moritz H. Albrecht ; Jan-Erik Scholtz ; Sarah C. Metzger ; Thomas Lehnert ; Thomas J. Vogl ; Julian L. Wichmann ; ^{docwichmann@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CAIPIRINHA ; Controlled Aliasing In Parallel Imaging Results In Higher Acceleration ; CI ; confidence interval ; CNR ; contrast-to-noise ratio ; CT ; computed tomography ; GFR ; glomerular filtration rate ; HASTE ; half-Fourier acquisition single-shot turbo spin-echo ; ICC ; intraclass correlation coefficient ; MRI ; magnetic resonance imaging ; pMRI ; parallel MRI ; SAR ; signal absorption rates ; SNR ; signal-to-noise ratio ; VIBE ; volumetric interpolated breath-hold examination
• 刊名：European Journal of Radiology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：85
• 期：1
• 页码：193-198
• 全文大小：1010 K

文摘

To evaluate the diagnostic accuracy, subjective image quality, and interobserver agreement of non-contrast Controlled Aliasing In Parallel Imaging Results In Higher Acceleration (CAIPIRINHA) volumetric interpolated breath-hold examination (VIBE) 3T magnetic resonance imaging (MRI) for the detection of pulmonary nodules with intra-individual comparison to computed tomography (CT).

Materials and methods

We evaluated 54 patients (27 male, 27 female; mean age, 60.8 ± 11.5 years) who prospectively underwent thoracic 3T-MRI using CAIPIRINHA-VIBE sequences and chest CT. Diagnostic accuracy for the detection of lung nodules on CAIPIRINHA-VIBE MRI by three independent observers were compared to the reference standard CT. Subjective image quality was rated using a 5-point grading scale. Diagnostic accuracy was calculated and interobserver agreement was assessed using intraclass correlation coefficient (ICC).

Results

Sensitivity of 3T-MRI for the detection of pulmonary lesions compared to CT was 88.1% (95% confidence interval [CI]: 0.81–0.93) and specifity was 79.1% (95% CI: 0.50–0.95). Sensitivity for lesions <5 mm was 77.2% (95% CI: 0.59–0.90) and for lesions from 5 to 10 mm was 87.2% (95% CI: 0.76–0.94). Sensitivity for lesions >10 mm was 100%. Observer ratings regarding subjective image quality were good to excellent for 3T-MRI (1.54) and CT (1.14) with almost perfect interobserver agreement for 3T-MRI and CT (ICC = 0.83, 95% CI: 0.78–0.89; ICC = 0.89, 95% CI: 0.85–0.94).

Conclusions

Non-contrast CAIPIRINHA-VIBE 3T-MRI allows for the reliable detection of pulmonary lesions with a diameter >5 mm in comparison with chest CT with high diagnostic accuracy, subjective image quality, and interobserver agreement.