In silico binding analysis and SAR elucidations of newly designed benzopyrazine analogs as potent inhibitors of thymidine phosphorylase
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- 作者：Muhammad Tahaa ; b ; taha_hej@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; muhamm9000@puncakalam.uitm.edu.my" class="auth_mail" title="E-mail the corresponding author ; Nor Hadiani Ismaila ; b ; Syahrul Imrana ; b ; Fazal Rahimd ; Abdul Wadoodc ; Laode Muhammad Ramadhan Al Muqarrabuna ; b ; Khalid Mohammed Khane ; Mehreen Ghufranc ; Muhammad Alif
- 关键词：Benzopyrazine ; Synthesis ; Thymidine phosphorylase inhibition ; Molecular docking ; SAR
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：80-89
- 全文大小：2738 K
文摘
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Synthesis of quinoxaline derivatives.
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In vitro thymidine phosphorylase inhibitory activity.
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Identification of a novel class of thymidine phosphorylase inhibitors.
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Structure-activity relationship established.
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Molecular docking studies.