The effect of statin therapy on thyroid autoimmunity in patients with Hashimoto's thyroiditis: A pilot study

详细信息    查看全文

• 作者：Robert Krysiak ; ^{r.krysiak@interia.pl" class="auth_mail" title="E-mail the corresponding author} ; Karolina Kowalcze ; Bogusław Okopień
• 关键词：HDL ; high-density lipoprotein ; HLA-DR ; human leukocyte antigen D-related ; HMG-CoA ; 3-hydroxy-3-methylglutaryl coenzyme A ; hsCRP ; high-sensitivity C-reactive protein ; LDL ; low-density lipoprotein ; SD ; standard deviation ; TgAb ; thyroglobulin antibodies ; TPOAb ; thyroid peroxidase antibodies
• 刊名：Pharmacological Reports
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：68
• 期：2
• 页码：429-433
• 全文大小：280 K

文摘

Statins have been found to exert antiinflammatory and immunomodulatory properties. The aim of this study was to compare the effects of intensive and less aggressive statin treatment on thyroid autoimmunity and hypothalamic-pituitary-thyroid axis activity in patients with Hashimoto's thyroiditis.

Methods

The study included 38 adult women with Hashimoto's thyroiditis, who required statin therapy and were allocated into one of two groups. Patients at very high cardiovascular risk (n = 16) received intensive statin treatment (rosuvastatin 20–40 mg daily), while patients at moderate or moderately high cardiovascular risk (n = 22) were treated with simvastatin (20–40 mg daily) for the following 6 months. Serum levels of thyrotropin, total and free thyroid hormones, and high-sensitivity C-reactive protein (hsCRP), as well as titers of thyroid peroxidase and thyroglobulin antibodies were measured at the beginning and at the end of the study.

Results

Thirty-six individuals completed the study and were included in the final analyses. Apart from improving plasma lipids and reducing circulating levels of hsCRP, intensive, but not less aggressive, statin therapy reduced thyroid peroxidase and thyroglobulin antibody titers, as well as tended to reduce circulating levels of thyrotropin. The effect of intensive statin therapy on thyroid antibody titers was lipid-independent but correlated with treatment-induced changes in thyrotropin and hsCRP.

Conclusions

Although 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors are able to reduce thyroid autoimmunity in women with Hashimoto's thyroiditis, intensive statin therapy is required to produce this effect.