Humoral and cellular autoimmunity in women with recurrent pregnancy losses and repeated implantation failures: A possible role of vitamin D

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• 作者：Joanne Kwak-Kim^a ; ^b ; ^{joanne.kwakkim@rosalindfranklin.edu" class="auth_mail" title="E-mail the corresponding author} ; Annie Skariah^a ; Li Wu^a ; Dinorah Salazar^a ; Nayoung Sung^a ; Kuniaki Ota^c
• 关键词：Recurrent pregnancy losses ; Repeated implantation failures ; Antiphospholipid antibody ; Autoimmunity ; NK cells ; Th1/Th2
• 刊名：Autoimmunity Reviews
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：15
• 期：10
• 页码：943-947
• 全文大小：356 K

文摘

Women with recurrent pregnancy losses (RPL) and repeated implantation failures (RIF) have auto- and cellular immune abnormalities. Approximately, 20% of women with RPL have autoimmune abnormalities, particularly antiphospholipid antibodies (APA). In addition, these women have a higher prevalence of antinuclear antibody, anti-thyroperoxidase and anti-thyroglobulin antibodies, and other non-organ-specific autoantibodies. In women with RPL, the presence of autoimmunity is often associated with cellular immune abnormalities, such as increased NK cell levels and Th1/Th2 cell ratios. Vitamin D (VD) plays a major role in regulation of auto- and cellular immune abnormalities. VD deficiency is prevalent in women with RPL, and women with VD deficiency have increased auto- and cellular immune abnormalities as compared with women with normal VD levels. VD has immune regulatory effects on various immune effectors including T, B and NK cells. Potential therapeutic application of VD for RPL and RIF with auto- and cellular immune abnormalities should be explored.