MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C/EBP-α pathway in intracerebral hemorrhage

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• 作者：Anyong Yu^b ; ¹ ; Tianxi Zhang^b ; ¹ ; Haizhen Duan^b ; Yong Pan^b ; Xiaojun Zhang^b ; Guang Yang^b ; Juan Wang^a ; Yi Deng^a ; Zhao Yang^a ; ^{yangzhao5140@sohu.com}
• 关键词：miR-124 ; M2 polarization ; Microglia ; Inflammation ; C/EBP-α ; ICH
• 刊名：Immunology Letters
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：1-11
• 全文大小：3376 K
• 卷排序：182

文摘

miR-124 was significantly increased in M2-polarized microglia. Transfection of miR-124 mimics decreased proinflammatory cytokine secretion. miR-124 decreased brain levels of C/EBP-α and significantly reduced brain injury in ICH mice.