A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation
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- 作者：Maninjay K. Atianand1 ; Wenqian Hu2 ; 6 ; Ansuman T. Satpathy3 ; Ying Shen3 ; Emiliano P. Ricci4 ; 7 ; Juan R. Alvarez-Dominguez2 ; Ankit Bhatta1 ; Stefan A. Schattgen1 ; Jason D. McGowan1 ; Juliana Blin1 ; Joerg E. Braun4 ; Pallavi Gandhi1 ; Melissa J. Moore4 ; Howard Y. Chang3 ; Harvey F. Lodish2 ; Daniel R. Caffrey1 ; Katherine A. Fitzgerald1 ; 5 ; kate.fitzgerald@umassmed.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：16 June 2016
- 年：2016
- 卷：165
- 期：7
- 页码：1672-1685
- 全文大小：2570 K
文摘
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lincRNA-EPS is downregulated in macrophages exposed to microbial ligands
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lincRNA-EPS represses the expression of immune response genes (IRGs)
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lincRNA-EPS controls nucleosome positioning and inhibits transcription of IRGs
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lincRNA-EPS-deficient mice manifest enhanced inflammation in vivo