Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway
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- 作者：Jianwei Zhang ; jianweizhangjwz@163.com" class="auth_mail" title="E-mail the corresponding author ; Qi Li ; Shaojin Zhang ; Quanquan Xu ; Tianen Wang
- 关键词：Lgr4 ; Prostate cancer ; Jmjd2a/AR ; Prostate-specific antigen (PSA)
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：349
- 期：1
- 页码：77-84
- 全文大小：1438 K
文摘
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Elevated Lgr4 induces the expression of Jmjd 2a in PCa cells.
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Jmjd 2a is involved in the regulation of Lgr4 to motility of PCa cells.
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There is a positive correlation between Jmjd 2a and AR in PCa cells.
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Lgr4 overexpression increases the interaction between Jmjd 2a with AR.
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Lgr4 induced-PSA transcription promotes PCa progression.