Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response
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- 作者：Stephanie Gras1 ; 2 ; 5 ; Jesseka Chadderton1 ; 3 ; 5 ; Claudia M. Del Campo1 ; 2 ; Carine Farenc1 ; Florian Wiede1 ; Tracy M. Josephs1 ; 2 ; Xavier Y.X. Sng1 ; 3 ; Michiko Mirams3 ; Katherine A. Watson3 ; 6 ; Tony Tiganis1 ; Kylie M. Quinn1 ; 3 ; Jamie Rossjohn1 ; 2 ; 4 ; jamie.rossjohn@monash.edu" class="auth_mail" title="E-mail the corresponding author ; Nicole L. La Gruta1 ; 3 ; 7 ; nicole.la.gruta@monash.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：reversed TCR docking ; T cell activation ; T cell recruitment ; TCR recognition of pMHCI
- 刊名：Immunity
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：45
- 期：4
- 页码：749-760
- 全文大小：3078 K
文摘
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TCRs found on naive T cells ligate pMHC-I in a 180° reversed orientation
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CD8+ T cells expressing “reversed” TCRs contribute minimally to the immune response
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Reversed TCR recognition drives limited signal transduction and T cell function
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Unconventionally docking TCRs may be prevalent in the naive pool