Analysis of Clinical Features and Outcomes of Skull Base Chordoma in Different Age-Groups

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• 作者：Kaibing Tian¹ ; ² ; ³ ; ⁴ ; Liang Wang¹ ; ² ; ³ ; ⁴ ; ^{saintage7@126.com" class="auth_mail" title="E-mail the corresponding author} ; Ke Wang¹ ; ² ; ³ ; ⁴ ; Junpeng Ma¹ ; ² ; ³ ; ⁴ ; Da Li¹ ; ² ; ³ ; ⁴ ; Shuyu Hao¹ ; ² ; ³ ; ⁴ ; Yang Yang¹ ; ² ; ³ ; ⁴ ; Jiang Du⁵ ; ⁶ ; ⁷ ; Guijun Jia¹ ; Liwei Zhang¹ ; ² ; ³ ; ⁴ ; Zhen Wu¹ ; ² ; ³ ; ⁴ ; Junting Zhang¹ ; ² ; ³ ; ⁴ ; ^{zhangjunting2003@aliyun.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Age ; Clinical feature ; Outcome ; Skull base chordoma
• 刊名：World Neurosurgery
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：92
• 期：Complete
• 页码：407-417
• 全文大小：7730 K

文摘

The objective of the current study was to compare the clinical features and outcomes between younger and older patients with skull base chordoma (SBC).

Methods

In this retrospective study, patients with SBC who underwent surgical treatment between February 2005 and December 2014 were included. Clinical features were recorded, including the signal intensity ratio of tumor to brain stem in T1 (R_T1), T2 (R_T2), and enhanced T1 (R_EN) sequences in primary patients with complete preoperative magnetic resonance images. The clinical features and outcomes were compared between younger (≤24 years) and older patients (≥25 years).

Results

In the present study, 238 patients were included. Younger patients experience more aggressive resection than do older patients (P = 0.045), and the SBCs of younger patients tended to be located in the occipitocervical region compared with older patients (P = 0.007). R_EN value in the younger group was lower than in the older group (P = 0.014), and the value of R_T2 was higher in younger patients than in older patients (P = 0.015). The risk of progression was higher in older patients compared with younger patients (P = 0.030); the risk of having a poor neurologic status in older patients was higher than in younger patients (P = 0.044).

Conclusions

In younger patients, there were more SBCs located in the occipitocervical regions, and younger patients tended to undergo more aggressive resection. The tumor signal intensity of younger patients with SBC was higher in T2 images but lower in enhanced T1 images. A younger age was a favorable factor for a longer progression-free survival and a good neurologic status at follow-up.