Sensitive analysis and simultaneous assessment of pharmacokinetic properties of crocin and crocetin after oral administration in rats

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• 作者：Yue Zhang^a ; Fei Fei^a ; Le Zhen^a ; Xuanxuan Zhu^b ; Jiankun Wang^a ; Sijia Li^a ; Jianliang Geng^a ; Runbin Sun^a ; Xiaoyi Yu^a ; Tingting Chen^c ; Siqi Feng^a ; Pei Wang^a ; Na Yang^a ; Yejin Zhu^a ; Jingqiu Huang^a ; Yuqing Zhao^a ; Jiye Aa^a ; ^{jiyea@cpu.edu.cn} ; Guangji Wang^a
• 关键词：Crocin ; Crocetin ; LC&ndash ; MS/MS ; Pharmacokinetics ; Bioavailability
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：1044-1045
• 期：Complete
• 页码：1-7
• 全文大小：1339 K
• 卷排序：1044

文摘

Crocin and crocetin were sensitively determined in rat plasma using LC/MS. Pharmacokinetic properties of crocin and crocetin was evaluated. Crocetin in plasma was much higher than crocin after orally given with crocin. Oral administration of crocin has the advantages over crocetin. Crocetin is the active component contributing to pharmacological effect of crocin.