Impact of glatiramer acetate on paraclinical markers of neuroprotection in multiple sclerosis: A prospective observational clinical trial
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- 作者：Rainer Ehling ; rainer.ehling@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Franziska Di Pauli franziska.dipauli@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Peter Lackner peter.lackner@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Carolyn Rainer carolyn.rainer@liverpool.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Viktoria Kraus viktoria.kraus@tirolkliniken.at" class="auth_mail" title="E-mail the corresponding author ; Harald Hegen harald.hegen@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Andreas Lutterotti andreas.lutterotti@usz.ch" class="auth_mail" title="E-mail the corresponding author ; Bettina Kuenz bettina.kuenz@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Tobias De Zordo tobias.de-zordo@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Michael Schocke michael.schocke@uni-ulm.de" class="auth_mail" title="E-mail the corresponding author ; Susanne Glatzl susanne.glatzl@reha-muenster.at" class="auth_mail" title="E-mail the corresponding author ; Wolfgang N. Lö ; scher wolfgang.loescher@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Florian Deisenhammer florian.deisenhammer@tirol-kliniken.at" class="auth_mail" title="E-mail the corresponding author ; Markus Reindl markus.reindl@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author ; Thomas Berger thomas.berger@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; brain-derived neurotrophic factor ; CE ; contrast enhancement ; CMCT ; central motor conduction time ; CSCT ; central sensory conduction time ; CSF ; cerebrospinal fluid ; DMTs ; disease modifying treatments ; EAE ; experimental autoimmune encephalomyelitis ; EDSS ; expanded disability status scale ; HRQoL ; health related quality of life ; LL-MEP ; lower limb motor evoked potential ; MBP ; myelin basic protein ; M-SEP ; median nerve somatosensory evoked potential ; MOG ; myelin oligodendrocyte glycoprotein ; MS
- 刊名：Journal of Neuroimmunology
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：287
- 期：Complete
- 页码：98-105
- 全文大小：709 K
文摘
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Investigation of GA-treated and therapy-naive MS-patients over 24 months
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Multimodal approach: serum BDNF, FACS, RT-PCR, evoked potentials, and cerebral MRI
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GA transiently increases serum IgG antibody response to MBP.
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GA does not alter BDNF serum or expression levels on peripheral immune cells.
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GA had no influence on neuropsychological, evoked potential and cerebral MRI outcome parameters.