Combined chemoassay and mass spectrometric approach to study the reactive potential of electrophiles towards deoxynucleosides as model for DNA
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- 作者：Maria I.H. Schmied-Tobies ; Heidrun Paschke ; Thorsten Reemtsma ; thorsten.reemtsma@ufz.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Risk assessment ; High resolution mass spectrometry ; Adductomics
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：263-270
- 全文大小：1095 K
文摘
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A chemoassay screening for reactivity of electrophiles towards DNA was established.
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Quinones were used for adduct formation showing so far unknown adducts.
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HRMSE was used for structure elucidation of adducts.