Circulating aldosterone and mortality in female nursing home residents

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• 作者：Andreas Tomaschitz^a ; ¹ ; ^{andreas.tomaschitz@gmx.at} ; ^{andreas.tomaschitz@medunigraz.at} ; Stefan Pilz^b ; ^c ; Burkert Pieske^a ; Eberhard Ritz^d ; Winfried Mä ; rz^e ; ^f ; ^g ; Andreas Meinitzer^e ; Harald Dobnig^b ; Karin Amrein^b ; Katharina Kienreich^b ; Nicolas Verheyen^a ; Elisabeth Kraigher-Krainer^a ; Christiane Drechsler^h ; Caterina Colantonio^a ; Doris Wagnerⁱ ; Astrid Fahrleitner-Pammer^b
• 关键词：Aldosterone ; Mortality ; Elderly female individuals ; Nursing home residents ; Heart failure
• 刊名：Experimental Gerontology
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：48
• 期：3
• 页码：313-318
• 全文大小：202 K

文摘

Objectives

To date studies evaluating the relation between circulating aldosterone levels and mortality in elderly female individuals are lacking. We therefore aimed to assess the relationship between circulating aldosterone levels and mortality in a population-based cohort study of female nursing home residents.

Methods

Individuals aged 70 years and older were recruited from 95 nursing homes in Austria. Participants were enrolled and followed up by mobile study teams. All participants underwent an extensive health examination and were followed until death or end of the study. Serum aldosterone concentration (SAC) was measured at baseline after exclusion of twenty seven patients taking mineralocorticoid-receptor (MR) blockers.

Results

Median SAC was 171.1 (IQR: 103.2-303.4) pg/mL (normal range: 30-400) in 471 female individuals (mean age: 83.7 ¡À 6.2 years). After a median follow-up of 27 ¡À 8 months, a total of 121 (25.7 % ) participants died. In multivariable Cox proportional hazard analysis, SAC levels stratified in quartiles were significantly associated with all-cause mortality. Compared with the reference (first) SAC quartile, the Cox proportional hazard ratio (confidence interval 95 % ) for the fourth SAC quartiles was 1.94, 95 % CI = 1.08-3.46, p = 0.026. We found statistically significant interaction terms between SAC-related mortality and the presence of advanced heart failure (NYHA functional class III; p = 0.038), HbA1c (p = 0.043) and eGFR levels (p = 0.030).

Conclusions

Higher circulating aldosterone levels are related to an increased mortality risk in elderly female nursing home residents. Interventional studies are needed to assess the potential influence of MR blockade on ¡°hard¡± clinical outcomes in individuals aged 70 years and older.