An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a

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• 作者：Giuseppe Del Giudice ; Anne Katrin Hilbert ; Roberto Bugarini ; Ada Minutello ; Olga Popova ; Daniela Toneatto ; Ines Schoendorf ; Astrid Borkowski ; Rino Rappuoli and Audino Podda
• 关键词：Influenza ; Vaccine ; Adjuvant ; Heterovariant
• 刊名：Vaccine
• 出版年：2006
• 出版时间：12 April 2006
• 年：2006
• 卷：24
• 期：16
• 页码：3063-3065
• 全文大小：71 K

文摘

To test whether inactivated influenza vaccines distributed during the 2003–2004 influenza season in the northern hemisphere were able to confer protection against the mismatched variant A/Fujian/411/2002 virus strain, we measured haemagglutination inhibiting (HI) antibodies in elderly subjects vaccinated with three inactivated vaccines against the homologous A/H3N2 vaccine strain (A/Panama) and against the mismatched A/Fujian strain. The results showed that, while 76 to 80 % of elder people vaccinated with conventional vaccines had protected levels of antibodies against the A/Fujian heterovariant strain, those vaccinated with the MF59-adjuvanted vaccine have protective levels of antibodies in >98 % of the cases. We conclude that MF59-adjuvanted vaccines confer protection also against influenza virus strains which are not fully matched with those included in the vaccine.