Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue
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- 作者：Katja Drä ; gerta ; b ; Indranil Bhattacharyaa ; b ; Michael N. Hallc ; Rok Humara ; b ; Edouard Battegaya ; b ; d ; Elvira Haasa ; b ; Elvira.haas@usz.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：mTORC2 ; Rictor ; Diurnal ; mSIN1 ; PKCalpha
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 April 2016
- 年：2016
- 卷：473
- 期：1
- 页码：317-322
- 全文大小：709 K
文摘
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Expression of Rictor, mTOR, and mSIN1 is diurnally regulated in brown adipose tissue.
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mTORC2 activity in terms of PKCα phosphorylation displays diurnal variation in perivascular adipose tissue (PVAT).
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Higher mTORC2 activity at zeitgeber time 14 is associated with lower expression of the inflammatory molecules Nos2 and Tnfα.