Advanced Analysis Techniques Improve Infant Bone and Body Composition Measures by Dual-Energy X-Ray Absorptiometry

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• 作者：John A. Shepherd ; PhD¹ ; ^{John.Shepherd@ucsf.edu} ; Markus J. Sommer ; BS¹ ; Bo Fan ; MD¹ ; Cassidy Powers ; BS¹ ; Lynda Stranix-Chibanda ; MBChB ; MMed² ; Amanda Zadzilka ; BS³ ; Michael Basar ; BA³ ; Kathy George ; MPH³ ; Cynthia Mukwasi-Kahari ; BSc² ; George Siberry ; MD ; MPH⁴
• 关键词：bone mineral density ; body composition ; precision
• 刊名：The Journal of Pediatrics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：181
• 期：Complete
• 页码：248-253.e3
• 全文大小：1139 K
• 卷排序：181

文摘

To evaluate a novel technique designed to reduce the negative impact of motion artifacts in infant dual-energy X-ray absorptiometry (DXA) scans.Study designUsing cross-sectional data from a large multicenter study, we developed and tested advanced methods for infant scan analysis. Newborns (n = 750) received spine and whole-body DXA scans with up to 3 attempts to acquire a motion free scan. Precision of infant DXA was estimated from visits with multiple valid scans. Accuracy of regional reflection, fusion, and omission techniques was estimated by comparing modified scans to unmodified valid scans. The effectiveness of the acquisition and analysis protocol was represented by the reduction in rate of failure to acquire valid results from infant visits.ResultsFor infant whole-body DXA, arm reflection and all fusion techniques caused no significant changes to bone mineral content, bone mineral density, bone area, total mass, fat mass, lean mass, and percentage fat. Leg reflection and arm/leg dual-reflection caused significant changes to total mass, but the percentage change remained small. For infant spine DXA, fusion and omission caused no significant changes. Advanced analysis techniques reduced the failure rate of whole-body scanning from 20.8% to 9.3% and the failure rate of spine scanning from 8.9% to 2.4%.ConclusionsAdvanced analysis techniques significantly reduced the impact of motion artifacts on infant DXA scans. We suggest this protocol be used in future infant DXA research and clinical practice.