Acute, 28 days sub acute and genotoxic profiling of Quercetin-Magnesium complex in Swiss albino mice

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• 作者：Nilanjan Ghosh^a ; Rajendra Sandur^b ; ^{drrajendra1972@gmail.com} ; Deepanwita Ghosh^a ; Souvik Roy^c ; Suresh Janadri^d ; ^{sureshjanadri@gmail.com}
• 关键词：Quercetin-Magnesium complex ; Acute toxicity ; Repeated oral dose toxicity ; Ames text ; Chromosomal aberration test ; Bone marrow micro nucleus assay
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：86
• 期：Complete
• 页码：279-291
• 全文大小：6885 K
• 卷排序：86

文摘

Quercetin-Magnesium complex is one of the youngest alkaline rare earth metal (Magnesium) complexes with flavonoids (Quercetin) in organo-metalic family. Earlier studies describe the details of the complex formation, characterization and antioxidant study of the complex but toxicity profile is still under darkness. The present study was taken up to investigate the oral acute toxicity, 28 days repeated oral sub-acute toxicity study and genotoxicity study of Quercetin-Magnesium complex in Swiss albino mice. Quercetin-Magnesium complex showed mortality at a dose of 185 mg/kg in the Swiss albino mice. In 28 days repeated oral toxicity study, Quercetin-Magnesium complex was administered to both sex of Swiss albino mice at dose levels of 150, 130 and 100 mg/kg body weight respectively. Where 150 mg/kg dose shows increased levels of white blood cells and changes in total protein, serum creatinine and blood urea nitrogen. Histopathological study of Quercetin-Magnesium complex shows minor structural alteration in kidney at 150 mg/kg dose. No observed toxic level found in 130 mg/kg or below doses. No genotoxic effect found in any doses of the complex. Therefore 130 mg/kg or below dose level could be better for further study.