Whole-body aerosol exposure of cadmium chloride (CdCl2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice
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- 作者：Yuanhong Chena ; 1 ; Yabing Hua ; 1 ; Shuyun Liua ; Huiying Zhenga ; Xiaojuan Wua ; Zhengyu Huanga ; Hao Lia ; Baoqi Penga ; Jinlie Longa ; Bishu Panb ; Changjiang Huanga ; cjhuang5711@163.com" class="auth_mail" title="E-mail the corresponding author ; Qiaoxiang Donga ; dqxdong@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tetrabromobisphenol A ; Cadmium ; Hepatic toxicity ; Inhalation toxicity ; Oxidative stress marker
- 刊名：Journal of Hazardous Materials
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：318
- 期：Complete
- 页码：109-116
- 全文大小：2035 K
文摘
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Hepatotoxicity of TBBPA and Cd aerosol co-exposure was evaluated in CD-1 male mice.
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Hepatic changes include focal necrosis, increased organ weight, and elevated enzymes.
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TBBPA group exhibited highest hepatic toxicity followed by co-exposure and Cd groups.
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We did not observe any synergistic effect of hepatic toxicity between TBBPA and Cd.
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TBBPA/Cd suppressed antioxidant defensive mechanisms and increased oxidative stress.