Trace element and cytokine concentrations in patients with Fibrodysplasia Ossificans Progressiva (FOP): A case control study

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• 作者：Laura Hildebrand^a ; ^{Laura.hildebrand@charite.de} ; Timo Gaber^b ; ^{timo.gaber@charite.de} ; Peter Kü ; hnen^c ; ^{peter.kuehnen@charite.de} ; Rolf Morhart^d ; ^{rmorhart@web.de} ; Heinz Unterbö ; rsch^e ; ^{h.unterboersch@t-online.de} ; Lutz Schomburg^f ; ^{lutz.schomburg@charite.de} ; Petra Seemann^a ; ^{petra.seemann@charite.de}
• 关键词：Activin A ; Copper ; Selenium ; Zinc
• 刊名：Journal of Trace Elements in Medicine and Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：186-192
• 全文大小：1073 K
• 卷排序：39

文摘

FOP is a devastating disease with inflammation-related extra bone formation. Inflammation disturbs trace element metabolism by self-amplifying mechanisms. Surprisingly, serum concentrations of Cu, Se and Zn are normal in FOP patients. Proinflammatory cytokine and Activin A levels are also undisturbed in FOP. Our findings exclude ongoing systemic chronic inflammations in FOP patients.