Endoplasmic reticulum stress and apoptosis via PERK-eIF2α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury

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• 作者：Yu-han Gu^a ; Yun Wang^a ; ^{ywang28@cmu.edu.cn} ; Yang Bai^a ; Ming Liu^b ; Huai-liang Wang^a ; ^c
• 关键词：MA ; methamphetamine ; ER ; endoplasmic reticulum ; ERS ; endoplasmic reticulum stress ; UPR ; unfolded protein response ; IRE1 ; inositol requiring kinase 1 ; PERK ; protein kinase-like ER kinase ; ATF6 ; transcriptional factor activating transcription factor 6 ; GRP78 ; glucose-regulated protein 78  ; kDa ; eIF2α ; eukaryotic initiation factor 2 alpha ; ROS ; reactive oxygen species ; IHC ; immunohistochemistry
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：194-201
• 全文大小：2461 K
• 卷排序：49

文摘

Severe ERS is involved in MA-induced the chronic pulmonary injury. PERK pathway is activated in MA-induced the chronic pulmonary injury. ERS-mediated apoptosis via PERK signaling in chronic pulmonary injury by MA.