Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells
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- 作者：Qianqian Xua ; Rong Fua ; Guoxiao Yina ; Xiulan Liua ; Yang Liub ; Ming Xianga ; xiangming@mails.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP ; Acute pancreatitis ; BACH1 ; BTB and CNC homology 1 ; basic leucine zipper transcription factor 1 ; BACH2 ; BTB and CNC homology 1 ; basic leucine zipper transcription factor 2 ; CARD9 ; Caspase recruitment domain family ; member 9 ; CDK4 ; Cyclin-dependent kinase 4 ; CDKN2A ; Cyclin-dependent kinase inhibitor 2A ; c-fos ; FBJ murine osteosarcoma viral oncogene homolog ; c-Jun ; Jun proto-oncogene ; CLDN2 ; Claudin 2 ; DAVID ; The Database for Annotation ; Visualization ; and Integrated Discovery ; DEGs ; Differenti
- 刊名：Gene
- 出版年：2016
- 出版时间：10 March 2016
- 年：2016
- 卷：578
- 期：2
- 页码：263-273
- 全文大小：2396 K
文摘
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We compare genetic profiles of the metastatic pancreatic cancer cell line SW1990 with two control cell lines.
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We identify genes and pathways in SW1990 cells that are induced by treatment with REG3A or IL6.
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We confirm eight genes and four pathways of REG3A on tumorigenesis in SW1990.
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REG3A shares similar molecular mechanism with IL6.
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Regulation network analysis uncovers three transcription factor families with immune functions regulated by REG3A.