Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors
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- 作者：Cá ; tia L. Marquesa ; b ; c ; M. Leonor Cancelaa ; c ; Vincent Laizé ; a ; vlaize@ualg.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMP ; bone morphogenetic protein ; RUNX ; Runt related transcription factor ; SOX ; SRY (sex determining region Y)-box ; TF ; transcription factor ; CBFß ; core binding factor ß ; MEF ; myocyte enhancer factor ; ETS ; v-ets avian erythroblastosis virus E26 oncogene homolog ; Fluc ; firefly luciferase ; Rluc ; Renilla luciferase
- 刊名：Gene
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：576
- 期：1
- 页码：229-236
- 全文大小：576 K
文摘
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Structure of bone morphogenetic protein 2 (BMP2) gene is conserved throughout evolution.
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Binding sites for bone/cartilage-related transcription factors are present in BMP2 promoter.
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Negative regulation of BMP2 transcription by RUNX3 is enhanced by CBFβ.
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20">MEF2C reduces BMP2 promoter activity in the presence of SOX9.
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25">ETS1 is an enhancer of BMP2 promoter activity.