Single-Cell Transcriptomic Analysis Defines Heterogeneity and Transcriptional Dynamics in the Adult Neural Stem Cell Lineage

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• 作者：Ben W. Dulken¹ ; ² ; ³ ; Dena S. Leeman¹ ; ⁴ ; Sté ; phane C. Boutet⁵ ; Katja Hebestreit¹ ; Anne Brunet¹ ; ⁶ ; ⁷ ; ^{abrunet1@stanford.edu}
• 关键词：neural stem cells ; adult neurogenesis ; single-cell RNA-seq ; machine learning ; pseudotemporal ordering
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：777-790
• 全文大小：7383 K
• 卷排序：18

文摘

Single-cell RNA-seq to characterize adult neural stem cell populations Machine learning and pseudotemporal ordering show a continuum in the lineage Validation of an intermediate state in the neural stem cell population Meta-analysis with other in vitro and in vivo single-cell datasets