Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication

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• 作者：Jeannine Wegner^a ; ^b ; Karin Loser^b ; ^c ; Gunita Apsite^a ; ^b ; Roswitha Nischt^d ; Beate Eckes^d ; Thomas Krieg^d ; Sabine Werner^e ; Lydia Sorokin^a ; ^b ; ^{sorokin@uni-muenster.de}
• 关键词：BM ; basement membrane ; ECM ; extracellular matrix ; TNF-α ; transforming growth factor-α ; IL-6 ; interleukin-6 ; KGF ; keratinocyte growth factor ; FGF ; fibroblast growth factor ; VEGF ; vascular endothelial growth factor ; CTGF ; connective tissue growth factor ; EGF ; epidermal growth factor ; TGF-β1 ; transforming growth factor ; IGF-1 ; insulin-like growth factor-1 ; FGFR2IIIb ; FGF-receptor-2α (IIIb)-Fc chimera ; DCs ; dendritic cells
• 刊名：Matrix Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：56
• 期：Complete
• 页码：24-41
• 全文大小：2856 K
• 卷排序：56

文摘

Vascular laminins α4 and α5 are not essential for blood vessel development Vascular laminins α4 and α5 are essential for vessel maturation and function Low laminin α5 in endothelial BMs define sites of leukocyte extravasation in postcapillary venules Laminin α5 in endothelial BMs of arterioles plays a role in mechanotransduction