An in silico approach to investigate the source of the controversial interpretations about the phenotypic results of the human AhR-gene G1661A polymorphism
详细信息 查看全文
- 作者：Younes Aftabia ; Abasalt Hosseinzadeh Colagara ; ahcolagar@umz.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Faramarz Mehrnejadb
- 关键词：TCDD ; 2 ; 3 ; 7 ; 8-tetrachlorodibenzop-dioxin ; FICZ ; 6-formylindolo [3 ; 2-b] carbazole ; ARNT ; AhR nuclear translocator ; R ; Arginine ; AhR ; Aryl hydrocarbon receptor ; bHLH ; Basic helix-loop-helix ; K ; Lysine ; PAS ; Per-ARNT-Sim ; PTM ; Post translational modification ; PPI ; Protein&ndash ; protein interaction ; SNPs ; Single nucleotide polymorphisms ; TBP ; TATA binding protein ; TAD ; Transactivation domain ; XREs ; Xenobiotic response elements ; BS ; Bayesian statistics ; MLR ; Multiple linear regression ; DT ; Decision t
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：21 March 2016
- 年：2016
- 卷：393
- 期：Complete
- 页码：1-15
- 全文大小：2404 K
文摘
- •
AhR- G1661A causes an arginine to lysine substitution in the acidic sub-domain of AhR-TAD with controversial phenotypic results.
- •
We investigated the possible effects by multiple in silico analysis.
- •
Secondary structure, solvent accessibility and pattern of the binding site and post translational modification predicted to be changed in the region.
- •
The predicted changes may alter the interactions of TAD, especially with TATA-binding protein.
- •
The flexibility of TAD could act as a moderating factor and causes distinct outcomes.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |