Comparative liver accumulation of dioxin-like compounds in sheep and cattle: Possible role of AhR-mediated xenobiotic metabolizing enzymes
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- 作者：F. Girolamia ; flavia.girolami@unito.it" class="auth_mail" title="E-mail the corresponding author ; V. Spalenzaa ; veronica.spalenza@unito.it" class="auth_mail" title="E-mail the corresponding author ; A. Benedettob ; Alessandro.Benedetto@izsto.it" class="auth_mail" title="E-mail the corresponding author ; L. Manzinia ; livio.manzini@unito.it" class="auth_mail" title="E-mail the corresponding author ; P. Badinoa ; paola.badino@unito.it" class="auth_mail" title="E-mail the corresponding author ; M.C. Abeteb ; MariaCesarina.Abete@izsto.it" class="auth_mail" title="E-mail the corresponding author ; C. Nebbiaa ; carlo.nebbia@unito.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AhR ; aryl hydrocarbon receptor ; ARNT ; AhR-nuclear translocator ; CDNB ; 1-chloro-2 ; 4-dinitrobenzene ; CHP ; cumene hydroperoxide ; CYP ; cytochrome P450 ; DCPIP ; 2 ; 6-dichlorophenolindophenol ; DL ; dioxin-like ; EFSA ; European Food Safety Authority ; EROD ; 7-ethoxyresorufin O-dealkylase ; GST ; glutathione S-transferase ; ICG ; internal control gene ; ML ; maximum level ; MROD ; 7-methoxyresorufin O-dealkylase ; NDL ; non-dioxin-like ; NQO1 ; quinone oxidoreductase ; PCB ; polychlorinated biphenyl ; PCDD ; polychlorinated
- 刊名：Science of the Total Environment
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：571
- 期：Complete
- 页码：1222-1229
- 全文大小：584 K
文摘
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Ovine liver specifically accumulates DL-compounds even in low contaminated areas.
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The role of biotransformation enzymes was explored in livers from sheep and cows.
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AhR signaling pathway and mediated enzymes were studied at gene and protein levels.
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CYP1 family is much less expressed in ovine versus bovine liver.
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Indirect evidence suggests a less efficient degradation of DL-compounds in sheep.
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