Predictors of 30-day post-transplant mortality in patients bridged to transplantation with continuous-flow left ventricular assist devices—An analysis of the International Society for Heart and Lung Transplantation Transplant Registry

详细信息    查看全文

• 作者：Aaron H. Healy ; MD^a ; Josef Stehlik ; MD^b ; Leah B. Edwards ; PhD^c ; Stephen H. McKellar ; MD ; MSc^a ; Stavros G. Drakos ; MD ; PhD^b ; Craig H. Selzman ; MD^a ; ^{craig.selzman@hsc.utah.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ventricular assist device ; transplantation ; outcomes ; continuous flow ; bridge to transplant
• 刊名：Journal of Heart and Lung Transplantation
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：35
• 期：1
• 页码：34-39
• 全文大小：752 K

文摘

Continuous-flow (CF) left ventricular assist devices (LVADs) are standard of care for bridging patients to cardiac transplantation. However, existing data about preoperative factors influencing early post-transplant survival in these patients are limited. We sought to determine risk factors for mortality using a large international database.

Methods

All patients in the International Society for Heart and Lung Transplantation Transplant Registry who were bridged to transplantation with CF LVADs between June 2008 and June 2012 were included. Risk factors for mortality within 30 days of transplant were identified. Statistical analysis included multivariable analysis and Kaplan-Meier survival analysis.

Results

During the study period, 2,152 patients with CF LVADs underwent heart transplantation. Post-transplant survival was 95.5% at 30 days. Risk factors for mortality during this window included ventilator support at transplant (hazard ratio [HR] = 5.00, 95% confidence interval [CI] = 1.51–16.58), female recipient/male donor (compared with all other combinations, HR = 3.29, 95% CI = 1.90–5.72), history of hemodialysis (HR = 2.51, 95% CI = 1.14–5.51), and history of coronary bypass grafting (HR = 1.89, 95% CI = 1.19–3.00). Increasing recipient age (p = 0.002), body mass index (p = 0.002), creatinine (p = 0.004), and total bilirubin (p < 0.001) also were associated with an increase in mortality.

Conclusions

In patients supported with CF LVADs, risk factors for early mortality can be identified before transplant, including ventilator support, female recipient/male donor, increasing recipient age, and body mass index. Despite the inherent complexities of a reoperative surgery, patients bridged to transplant with CF LVADs have excellent peri-operative survival.