Blocking inhibition to YAP by ActinomycinD enhances anti-tumor efficacy of Corosolic acid in treating liver cancer

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• 作者：Yanfeng Xu^a ; ¹ ; Yinghui Zhao^b ; ¹ ; Yanli Xu^c ; Yu Guan^d ; Xiao Zhang^b ; Yan Chen^b ; Qi Wu^b ; Guoqing Zhu^b ; Yuxin Chen^b ; Fenyong Sun^b ; Jiayi Wang^b ; ^e ; ^{karajan2@163.com} ; Yongchun Yu^f ; ^{yueyongchun88@163.com}
• 关键词：Chemotherapy ; YAP ; Protein stability ; Transformative phenotypes ; βTrCP
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：29
• 期：Complete
• 页码：209-217
• 全文大小：1664 K
• 卷排序：29

文摘

Corosolic acid plays pro-apoptotic roles in liver cancer cells; Down-regulation of YAP reduces efficacy of Corosolic acid; Corosolic acid-induced degradation of YAP is associated with βTrCP and LATS1; ActinomycinD enhances efficacy of Corosolic acid via YAP and βTrCP; ActinomycinD reduces IC50 value of Corosolic acid in treating liver cancer.