Asymmetric benzoin condensation promoted by chiral triazolium precatalyst bearing a pyridine moiety

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• 作者：Takahiro Soeta  ; ;   ; ^{soeta@se.kanazawa-u.ac.jp} ; Yuhta Tabatake ; Katsuhiko Inomata ; Yutaka Ukaji 
• 关键词：N-Heterocyclic carbene ; Catalytic asymmetric reaction ; Benzoin condensation
• 刊名：Tetrahedron
• 出版年：2012
• 出版时间：21 January 2012
• 年：2012
• 卷：68
• 期：3
• 页码：894-899
• 全文大小：696 K

文摘

Chiral triazolium salts bearing a pyridine ring were developed as N-heterocyclic carbene precursors. In the presence of the chiral triazolium salt and a base, the catalytic asymmetric benzoin condensation proceeded to afford the product in high level of chemical yield and enantioselectivity. A wide range of aromatic aldehydes were applicable to this reaction.