The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23

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• 作者：Michaela C. Hohnholt^a ; ^{hohnholt@uni-bremen.de} ; Eva-Maria Blumrich^b ; ^c ; Helle S. Waagepetersen^a ; Ralf Dringen^b ; ^c
• 关键词：Astrocytes ; Lactate ; Metabolism ; Tyrphostins ; Tricarboxylic acid cycle
• 刊名：Neurochemistry International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：13-21
• 全文大小：1136 K
• 卷排序：102

文摘

T23 stimulates glycolytic flux in cultured astrocytes. Molecular carbon labeling from [U-13C]glucose is enhanced in tricarboxylic acid cycle intermediates. Mitochondrial metabolism of brain astrocytes is accelerated by T23 exposure.