Immunomodulatory potential of particular Trichinella spiralis muscle larvae excretory-secretory components

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• 作者：J. Cvetkovic^a ; ^{jelenac@inep.co.rs} ; Lj. Sofronic-Milosavljevic^a ; N. Ilic^a ; M. Gnjatovic^a ; I. Nagano^b ; A. Gruden-Movsesijan^a
• 关键词：Trichinella spiralis ; Immunomodulation ; Excretory&ndash ; secretory antigens ; 7C2C5Ag ; rTsp53
• 刊名：International Journal for Parasitology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：46
• 期：13-14
• 页码：833-842
• 全文大小：1344 K
• 卷排序：46

文摘

7C2C5Ag and rTsp53 possess capacity to induce Trichinella spiralis-influenced semi-mature status of dendritic cells (DCs). Weak activation of both kinases (ERK, p38) in stimulated DCs proved to be sufficient for Th2 polarisation in vitro. 7C2C5Ag and rTsp53 may contribute to a Th2 shift, an observed immunomodulatory effect of Trichinella ES L1 products.