Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination

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• 作者：Antonio Bermejo Gó ; me^a ; ^c ; ^{antonio.bermejo-gomez@astrazeneca.com} ; Miguel A. Corté ; s Gonzá ; lez^b ; ^c ; Marvin Lü ; bcke^b ; ^c ; Magnus J. Johansson^d ; Magnus Schou^a ; ^c ; Ká ; lmá ; n J. Szabó ; ^b ; ^c ;
• 关键词：Nucleophilic fluorination ; Copper ; Trifluoroacetate ; Trifluoromethylarene ; Trifluoroacetamide
• 刊名：Journal of Fluorine Chemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：194
• 期：Complete
• 页码：51-57
• 全文大小：779 K
• 卷排序：194

文摘

Nucleophilic fluorodebromination using a copper (I) fluoride complex. Trifluoroacetates, trifluoroacetamides and electron poor trifluormethyl arenes obtained in high yields. Good functional group tolerance.