The effect of memantine on trinitrobenzene sulfonic acid-induced ulcerative colitis in mice

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• 作者：Ehsan Motaghi^a ; Valiollah Hajhashemi^a ; Parvin Mahzouni^b ; Mohsen Minaiyan^a ; ^{minaiyan@pharm.mui.ac.ir}
• 关键词：Memantine ; NMDA receptors ; Colitis ; Antagonist ; Inflammation ; Mice
• 刊名：European Journal of Pharmacology
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：793
• 期：Complete
• 页码：28-34
• 全文大小：596 K
• 卷排序：793

文摘

Previous reports suggest a significant role for N-Methyl-D-aspartate (NMDA) activation in inflammatory processes. So, this study was conducted to investigate the effect of memantine, a commonly used NMDA receptor antagonist, on inflammatory changes in mice model of colitis. Colitis was induced by intracolonic instillation of trinitrobenzene sulfonic acid (TNBS) (40 mg/kg). Animals received memantine (12.5, 25 and 50 mg/kg, i.p.), glutamate (2 g/kg, p.o.) or dexamethasone (1 mg/kg, i.p.) 24 h before TNBS instillation and daily thereafter for 4 days. The colonic injury was measured by clinical, macroscopic, microscopic and biochemical analysis. Memantine significantly attenuated the body weight loss, colon weight, the plasma levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and colon level of tumor necrosis factor-α (TNF-α) and myeloperoxidase (MPO); as well as macroscopic and microscopic signs of colitis. Oral administration of glutamate had no significant effect on investigated parameters. Memantine as a NMDA antagonist may provide a novel venue for the development of strategies for the treatment of ulcerative colitis.